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Tapentadol is a centrally-acting, prescription opioid analgesic used to manage moderate to severe acute pain. It has a dual mechanism, working as both an opioid receptor agonist and a norepinephrine reuptake inhibitor. As a Schedule II controlled substance in the U.S., it carries a high risk for abuse, dependence, and severe side effects like respiratory depression. Its use requires strict medical supervision, is typically for short-term management, and is not suitable for individuals with a history of substance abuse.

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